Question 280 of 433
What is the scorecard for repurposed medicines?
The short answer
Here it is, ranked by the strength of the human evidence.
Proven to extend healthy life, in the people they are approved for
Blood pressure medicines.
Statins, ezetimibe, and PCSK9 inhibitors.
SGLT2 inhibitors (diabetes, heart failure, kidney disease).
GLP-1 medicines (obesity, diabetes, heart disease).
Menopause hormone therapy, started on time.
Vaccines.
Reasonable to discuss if you have an approved reason to take it
Daily low-dose tadalafil.
Metformin with prediabetes.
Low-dose colchicine with coronary disease.
Unproven for healthy people; wait for trials
Metformin, GLP-1 microdosing, and SGLT2 inhibitors without the conditions they treat.
Rapamycin.
Acarbose.
Low-dose lithium.
Do not take for longevity
Aspirin, without artery disease.
Growth hormone.
Testosterone, with normal levels.
Thyroid hormone, with normal levels.
“This book is for education. It is not medical advice, and reading it does not make you my patient or create a doctor-patient relationship.” From the book’s medical disclaimer. Full disclaimer
CLINICAL SYNTHESIS — Drug-by-drug indications and endpoints differ; no numerical cross-drug evidence score.Evidence grade (draft mapping)JClinical judgment / author synthesisPart 19, Q280 · Part sources
From Longevity Unmasked by Afshine Ash Emrani, MD, FACC. Medical disclaimer. This book is for education. It is not medical advice, and reading it does not make you my patient or create a doctor-patient relationship. Nothing here is meant to diagnose, treat, cure, or prevent any disease. Medicine is personal: a test, drug, supplement, or exercise plan that helps one person can harm another. Do not start, stop, or change any medication or treatment because of something you read in these pages. Talk with a licensed clinician who knows your history first. If you think you are having a medical emergency, call 911. The author disclaims responsibility for any loss or harm arising from use of the information in this book.