Evidence matrix (provisional)

Questions per part by the book’s defined evidence categories. Only scopes that match a category name exactly are counted in it; everything else is “Other / multiple” until the proposed grouping is approved. Hover a number to see each scope as printed.

Part	Total	ROBUST HUMAN TRIALS	LIMITED HUMAN STUDIES	SMALL HUMAN STUDIES	OBSERVATIONAL	PRECLINICAL	NOT DEMONSTRATED	GUIDELINE-BASED	REGULATORY STATUS	CLINICAL JUDGMENT	Other / multiple
1. The Truth About Aging	12	1			1	1	1	1			7
2. Lessons from the Longevity Giants	13									1	12
3. The Heart of the Matter	17	4									13
4. Know Your Numbers	13		1		1		2	1			8
5. The Advanced Testing Menu, Graded	31	2						5			24
6. Muscle and Movement	11	4			3						4
7. Sleep, Stress, and Mood	9	1			1						7
8. Sleep Apnea, the Silent Thief	9	1									8
9. Food, Fasting, and Alcohol	14				1						13
10. The Blue Zones Formula	7				1						6
11. Metabolism, Insulin Resistance, and the GLP-1 Era	23	4					2				17
12. Protecting Your Brain	16	2			1						13
13. Bones and Joints	12	3			1			1			7
14. Menopause, Hot Flashes, and a Woman’s Second Half	16	2			1			1			12
15. Testosterone and a Man’s Second Half	16	1			1			1			13
16. Cancer: Prevention and Early Detection	16	1					2	1	1		11
17. Supplements, Ranked by Evidence	22	2	1				1				18
18. The Longevity Drugs	10	1								1	8
19. Repurposing Today’s Medicines for Longevity	13	2									11
20. The Toy Chest: Every Drip, Device, and Gadget, Graded	33		2	2	1		4		1		23
21. The Med Spa Menu: Skin, Shape, and Sex	12			1							11
22. Mind, Body, and the Experimental Shelf	23		1	1							21
23. The Frontier: Regenerative Medicine	6					1	2				3
24. Gut, Inflammation, and Immunity	10										10
25. Inside the Longevity Industry	15						1				14
26. Clinics, Costs, and Scams	8										8
27. Everything Else You Wanted to Ask	22				1			2			19
28. What Is Coming	13										13
29. Purpose, People, and Your Plan	11				2						9

The testing scorecard

From Part 5, Q86: “Here it is on one page.”

FOUNDATIONS, selected for age and risk

Blood pressure at home.
Lipids with ApoB; Lp(a) once.
HbA1c or fasting glucose when diabetes screening is appropriate; an oral glucose tolerance test in selected cases.
hs-CRP only when it could clarify a cardiovascular risk decision.
Kidney function with urine albumin.
Liver assessment and FIB-4 when metabolic or other liver risks justify them.
Blood count, TSH, and ferritin if tired or at risk.
Heart calcium score at the right age.
Proven cancer screening.
Bone density at the right age.
Aortic aneurysm ultrasound for men 65 to 75 who smoked.
Hearing, vision, and a sleep test if you snore.
Grip, balance, walking speed, and a fitness measure.

SOMETIMES, for a reason

CT angiogram of the heart arteries.
Carotid ultrasound.
Cystatin C.
NT-proBNP in people with diabetes or high blood pressure.
Targeted genetic testing; pharmacogenomics.
APOE, with counseling.
PFAS blood level with known exposure.
A multi-cancer blood test, after standard screening.
A continuous glucose monitor for a few weeks.

SKIP

Food sensitivity panels.
Micronutrient, organic acid, and “leaky gut” tests.
Urine mold tests and provoked metal tests.
Saliva cortisol and dried-urine hormone panels.
MTHFR.
Reverse T3.
Inflammation panels beyond hs-CRP; NMR particle tests.
Telomere length.
Hair analysis, live blood analysis, thermography.
Whole-body MRI and brain volumetrics at average risk.

Evidence scope: CLINICAL SYNTHESIS — Testing categories apply to routine wellness use; specific indications can change the recommendation. Part sources