Question 149 of 433
What are the real risks?
The short answer
Nausea, constipation or diarrhea, and reflux are common, especially early. Gallstones, pancreatitis, and severe stomach slowing are uncommon but real. I also pay close attention to nutritional adequacy, strength, and function during weight loss.
Start low and go slow. Eat smaller meals. Tell your surgeon and anesthesiologist before any procedure, because a slow stomach changes the fasting instructions. These drugs should not be used by people with a personal or family history of medullary thyroid cancer or a syndrome called MEN 2, or during pregnancy.
And buy the real medicine. During the shortages, compounded and online versions flooded the market, some with dosing errors and some that were simply counterfeit.
“This book is for education. It is not medical advice, and reading it does not make you my patient or create a doctor-patient relationship.” From the book’s medical disclaimer. Full disclaimer
TRIALS / PHARMACOVIGILANCE — Indicated GLP-1 users: adverse effects and contraindications; absolute risks vary.Evidence grade (draft mapping)RRegulatory statusPart 11, Q149 · Sources: R3
Sources cited
- R3 Neeland IJ, Linge J, Birkenfeld AL. Changes in lean body mass with glucagon-like peptide-1-based therapies and mitigation strategies. Diabetes, Obesity and Metabolism. 2024;26(suppl 4):16–27. doi:10.1111/dom.15728. PubMed 38937282DOI 10.1111/dom.15728✓ Verified
From Longevity Unmasked by Afshine Ash Emrani, MD, FACC. Medical disclaimer. This book is for education. It is not medical advice, and reading it does not make you my patient or create a doctor-patient relationship. Nothing here is meant to diagnose, treat, cure, or prevent any disease. Medicine is personal: a test, drug, supplement, or exercise plan that helps one person can harm another. Do not start, stop, or change any medication or treatment because of something you read in these pages. Talk with a licensed clinician who knows your history first. If you think you are having a medical emergency, call 911. The author disclaims responsibility for any loss or harm arising from use of the information in this book.