Question 122 of 433
Does eating fewer calories slow aging?
The short answer
In animals, clearly. In humans, modestly and at a cost.
In the two-year CALERIE trial, healthy adults who reduced calories by about 12 percent slowed their pace of aging on the DunedinPACE clock by 2 to 3 percent and improved nearly every heart risk marker. They also lost some muscle and bone. For someone who is overweight, eating less is plainly good. For a lean person, deliberate long-term restriction risks trading metabolic benefit for frailty.
“This book is for education. It is not medical advice, and reading it does not make you my patient or create a doctor-patient relationship.” From the book’s medical disclaimer. Full disclaimer
HUMAN TRIAL — Healthy non-obese adults: calorie restriction changed risk markers and one aging measure; lifespan untested.Evidence grade (draft mapping)Grade pendingPart 9, Q122 · Part sources
From Longevity Unmasked by Afshine Ash Emrani, MD, FACC. Medical disclaimer. This book is for education. It is not medical advice, and reading it does not make you my patient or create a doctor-patient relationship. Nothing here is meant to diagnose, treat, cure, or prevent any disease. Medicine is personal: a test, drug, supplement, or exercise plan that helps one person can harm another. Do not start, stop, or change any medication or treatment because of something you read in these pages. Talk with a licensed clinician who knows your history first. If you think you are having a medical emergency, call 911. The author disclaims responsibility for any loss or harm arising from use of the information in this book.