Question 260 of 433
What are the risks of rapamycin?
The short answer
Mouth sores, higher cholesterol and triglycerides, higher blood sugar, slower wound healing, and, at higher doses, a weakened immune system.
Transplant patients take it daily at much higher doses. Longevity users take it weekly to allow recovery between doses, and that seems to reduce side effects. But “seems to” is carrying a lot of weight in that sentence. It interacts with many drugs and with grapefruit, and perioperative use needs an explicit plan from the prescribing and surgical teams.
“This book is for education. It is not medical advice, and reading it does not make you my patient or create a doctor-patient relationship.” From the book’s medical disclaimer. Full disclaimer
ESTABLISHED DRUG SAFETY / LIMITED LOW-DOSE DATA — Rapamycin risks; short trials cannot establish long-term healthy-user safety.Evidence grade (draft mapping)EEstablished clinical knowledgePart 18, Q260 · Part sources
From Longevity Unmasked by Afshine Ash Emrani, MD, FACC. Medical disclaimer. This book is for education. It is not medical advice, and reading it does not make you my patient or create a doctor-patient relationship. Nothing here is meant to diagnose, treat, cure, or prevent any disease. Medicine is personal: a test, drug, supplement, or exercise plan that helps one person can harm another. Do not start, stop, or change any medication or treatment because of something you read in these pages. Talk with a licensed clinician who knows your history first. If you think you are having a medical emergency, call 911. The author disclaims responsibility for any loss or harm arising from use of the information in this book.