Question 158 of 433
What about SGLT2 inhibitors?
The short answer
These diabetes pills turned out to protect the heart and kidneys in people with and without diabetes. They are proven medicines for those conditions, not general anti-aging pills.
Drugs such as empagliflozin and dapagliflozin make the kidneys release sugar into the urine. In large trials they reduced hospitalizations for heart failure and slowed kidney failure. One of them, canagliflozin, extended life in male mice. That is intriguing, but there are no trials in healthy people, and side effects include genital yeast infections and dehydration.
“This book is for education. It is not medical advice, and reading it does not make you my patient or create a doctor-patient relationship.” From the book’s medical disclaimer. Full disclaimer
ROBUST HUMAN TRIALS — Indicated heart failure, kidney disease, or diabetes populations: organ outcomes; general healthy-aging use unproven.Evidence grade (draft mapping)ARobust human trialsPart 11, Q158 · Part sources
From Longevity Unmasked by Afshine Ash Emrani, MD, FACC. Medical disclaimer. This book is for education. It is not medical advice, and reading it does not make you my patient or create a doctor-patient relationship. Nothing here is meant to diagnose, treat, cure, or prevent any disease. Medicine is personal: a test, drug, supplement, or exercise plan that helps one person can harm another. Do not start, stop, or change any medication or treatment because of something you read in these pages. Talk with a licensed clinician who knows your history first. If you think you are having a medical emergency, call 911. The author disclaims responsibility for any loss or harm arising from use of the information in this book.