Question 147 of 433
What are GLP-1 medicines, in plain language?
The short answer
They copy a natural gut hormone that tells the brain you are full, slows the stomach, and helps the pancreas control sugar.
Semaglutide (sold as Ozempic and Wegovy) copies one hormone. Tirzepatide (Mounjaro and Zepbound) copies two. In trials, average weight loss was about 15 percent with semaglutide and about 20 percent with tirzepatide over a little more than a year. Before these drugs, only surgery produced numbers like that.
Many patients describe something else too: the constant mental chatter about food goes quiet. For people who have fought their appetite for decades, that silence can be life-changing.
“This book is for education. It is not medical advice, and reading it does not make you my patient or create a doctor-patient relationship.” From the book’s medical disclaimer. Full disclaimer
ROBUST HUMAN TRIALS — Indicated adults with obesity or diabetes: GLP-1-based therapies improve weight or glucose control.Evidence grade (draft mapping)ARobust human trialsPart 11, Q147 · Part sources
From Longevity Unmasked by Afshine Ash Emrani, MD, FACC. Medical disclaimer. This book is for education. It is not medical advice, and reading it does not make you my patient or create a doctor-patient relationship. Nothing here is meant to diagnose, treat, cure, or prevent any disease. Medicine is personal: a test, drug, supplement, or exercise plan that helps one person can harm another. Do not start, stop, or change any medication or treatment because of something you read in these pages. Talk with a licensed clinician who knows your history first. If you think you are having a medical emergency, call 911. The author disclaims responsibility for any loss or harm arising from use of the information in this book.