Question 194 of 433
Which form of hormone therapy is best?
The short answer
For most women, estradiol through the skin, with oral micronized progesterone if they have a uterus.
Both are FDA approved, identical to the body’s own hormones, generic, and covered by insurance. The patch is changed once or twice a week; gels and sprays are applied daily. Progesterone is taken at bedtime and often helps sleep. Doses are adjusted to symptoms. There is no need for custom-compounded creams.
“This book is for education. It is not medical advice, and reading it does not make you my patient or create a doctor-patient relationship.” From the book’s medical disclaimer. Full disclaimer
GUIDELINE / CLINICAL JUDGMENT — Eligible women: route and progestogen choice; universal superiority is not established for every endpoint.Evidence grade (draft mapping)GGuideline-based / consensusPart 14, Q194 · Sources: R6
Sources cited
- R6 US Food and Drug Administration. FDA Approves Labeling Changes to Menopausal Hormone Therapy Products. February 12, 2026. Link pending verification
From Longevity Unmasked by Afshine Ash Emrani, MD, FACC. Medical disclaimer. This book is for education. It is not medical advice, and reading it does not make you my patient or create a doctor-patient relationship. Nothing here is meant to diagnose, treat, cure, or prevent any disease. Medicine is personal: a test, drug, supplement, or exercise plan that helps one person can harm another. Do not start, stop, or change any medication or treatment because of something you read in these pages. Talk with a licensed clinician who knows your history first. If you think you are having a medical emergency, call 911. The author disclaims responsibility for any loss or harm arising from use of the information in this book.