Question 345 of 433
Low-dose naltrexone, thymus regeneration, NAD patches, and clinic “stacks”?
The short answer
Each has a small study or a mouse study behind it, and none has shown a benefit for healthy aging.
Low-dose naltrexone is promoted for inflammation, pain, and immunity. A well-run trial in fibromyalgia found it no better than placebo.
Thymus regeneration with growth hormone, DHEA, and metformin was tested in nine men with no control group. Their epigenetic age fell. The larger follow-up study has not been published.
NAD patches, nasal glutathione, injectable spermidine, and 17-alpha estradiol have little or no human data.
When a clinic sells a “stack,” ask to see the trial of the stack. If there is no trial of the combination, evidence for its separate ingredients cannot establish the stack’s benefit or safety.
“This book is for education. It is not medical advice, and reading it does not make you my patient or create a doctor-patient relationship.” From the book’s medical disclaimer. Full disclaimer
LIMITED / PRECLINICAL / NEGATIVE — Heterogeneous experimental stacks; no demonstrated combined healthy-aging benefit.Evidence grade (draft mapping)BLimited or small human studiesPart 22, Q345 · Part sources
From Longevity Unmasked by Afshine Ash Emrani, MD, FACC. Medical disclaimer. This book is for education. It is not medical advice, and reading it does not make you my patient or create a doctor-patient relationship. Nothing here is meant to diagnose, treat, cure, or prevent any disease. Medicine is personal: a test, drug, supplement, or exercise plan that helps one person can harm another. Do not start, stop, or change any medication or treatment because of something you read in these pages. Talk with a licensed clinician who knows your history first. If you think you are having a medical emergency, call 911. The author disclaims responsibility for any loss or harm arising from use of the information in this book.