Longevity UnmaskedLongevity Unmasked

Question 328 of 433

Are ketamine clinics safe?

Evidence grade (draft mapping)ARobust human trials
Empty reclining therapy chair with blanket in dim navy room

The short answer

Ketamine can lift severe depression within hours, and for some people it is lifesaving. It belongs in a medical setting with monitoring, not in the mail.

Given by vein at a low dose, ketamine produces rapid relief that lasts days to a week. A nasal form, esketamine, is FDA approved under strict supervision. The older drug is used off-label. In 2023 the FDA warned about compounded ketamine sent to patients’ homes, citing abuse, dangerous sedation, blood pressure spikes, and bladder damage. This is a powerful anesthetic. It is treatment for illness, not a wellness experience.

“This book is for education. It is not medical advice, and reading it does not make you my patient or create a doctor-patient relationship.” From the book’s medical disclaimer. Full disclaimer

Evidence scope
ROBUST SHORT-TERM HUMAN TRIALS — Selected resistant depression: supervised ketamine or esketamine; maintenance, monitoring, and risks matter.Evidence grade (draft mapping)ARobust human trialsPart 22, Q328 · Part sources
All of Part 22

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