Longevity UnmaskedLongevity Unmasked

Question 154 of 433

What if I do not lose weight on a GLP-1?

Evidence grade (draft mapping)GGuideline-based / consensus
Bathroom scale with display on sunlit tiles, bare feet

The short answer

You are not doing it wrong. About one in ten people respond poorly to a given drug, for biological reasons.

Check the basics first: the dose may still be too low, the pharmacy product may not be what it claims, other medications may be working against you, and sleep apnea, alcohol, or an underactive thyroid may be in the way. Some people who do not respond to one drug respond to another. For years we told people to eat less and move more and blamed them when biology won. That was unkind and it was wrong.

“This book is for education. It is not medical advice, and reading it does not make you my patient or create a doctor-patient relationship.” From the book’s medical disclaimer. Full disclaimer

Evidence scope
TRIAL VARIABILITY / CLINICAL GUIDANCE — Adults treated for obesity: responses differ; investigate dose, tolerance, and clinical factors.Evidence grade (draft mapping)GGuideline-based / consensusPart 11, Q154 · Part sources
All of Part 11

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