Longevity UnmaskedLongevity Unmasked

Question 139 of 433

Can prediabetes be reversed?

Evidence grade (draft mapping)ARobust human trials
Round glucose sensor on an anonymous upper arm, outdoors in daylight

The short answer

Glucose levels can return below the prediabetes range, and progression can often be delayed. In a major prevention trial, intensive lifestyle change outperformed metformin on average.

In the landmark Diabetes Prevention Program, people with prediabetes who lost about 7 percent of their weight and walked 150 minutes a week cut their risk of diabetes by 58 percent. Metformin cut it by 31 percent. The benefit was still visible more than twenty years later. Losing fat from the liver and the belly, building muscle, and walking for ten minutes after meals are the three most effective moves.

“This book is for education. It is not medical advice, and reading it does not make you my patient or create a doctor-patient relationship.” From the book’s medical disclaimer. Full disclaimer

Evidence scope
ROBUST HUMAN TRIAL — High-risk adults with prediabetes: intensive lifestyle reduced diabetes incidence; not universal reversal.Evidence grade (draft mapping)ARobust human trialsPart 11, Q139 · Part sources
All of Part 11

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