Question 412 of 433
What is next for Lp(a) and blood pressure?
The short answer
Two more Lp(a) drugs are in large trials after the first one failed, and a blood pressure injection given twice a year is in a major outcomes study.
For Lp(a), olpasiran and lepodisiran lower the particle even more deeply than the drug that failed in 2026. Their results are expected in 2028 and 2029. They will test whether these particular treatments reduce events. A negative drug trial would not, by itself, erase genetic and other evidence that Lp(a) contributes causally to cardiovascular disease.
For blood pressure, an injection called zilebesiran silences a liver gene involved in raising pressure, and one dose lasts six months. A trial in about 11,000 people began in late 2025 to see whether it prevents heart attacks and strokes. For the many patients who forget daily pills, this could matter a great deal.
“This book is for education. It is not medical advice, and reading it does not make you my patient or create a doctor-patient relationship.” From the book’s medical disclaimer. Full disclaimer
ONGOING HUMAN RESEARCH — Specific Lp(a) and BP drugs: biomarker effects do not establish outcome benefit.Evidence grade (draft mapping)Grade pendingPart 28, Q412 · Sources: R9
Sources cited
- R9 Novartis. Lp(a)HORIZON phase III topline results for pelacarsen in patients with elevated Lp(a) and established cardiovascular disease. September 4, 2026. Link pending verification
From Longevity Unmasked by Afshine Ash Emrani, MD, FACC. Medical disclaimer. This book is for education. It is not medical advice, and reading it does not make you my patient or create a doctor-patient relationship. Nothing here is meant to diagnose, treat, cure, or prevent any disease. Medicine is personal: a test, drug, supplement, or exercise plan that helps one person can harm another. Do not start, stop, or change any medication or treatment because of something you read in these pages. Talk with a licensed clinician who knows your history first. If you think you are having a medical emergency, call 911. The author disclaims responsibility for any loss or harm arising from use of the information in this book.