Question 263 of 433
Do senolytic drugs work in people?
The short answer
Not yet proven. Early human trials are small, and results have been mixed.
Senolytics are drugs meant to kill zombie cells. The most studied combination is dasatinib, a leukemia drug, with quercetin, a plant compound. Small pilot studies showed it could reduce senescent cells in human tissue. But a trial for bone health in older women found no overall benefit, and a company’s senolytic for knee arthritis failed. Fisetin, a compound in strawberries sold widely as a supplement, did not extend life in the federal mouse program, and human trials are still in progress.
Dasatinib is a chemotherapy drug with real toxicity. This is not something to try at home.
“This book is for education. It is not medical advice, and reading it does not make you my patient or create a doctor-patient relationship.” From the book’s medical disclaimer. Full disclaimer
SMALL / MIXED HUMAN TRIALS — Senolytics: no established general healthy-aging benefit; drug toxicity is real.Evidence grade (draft mapping)BLimited or small human studiesPart 18, Q263 · Part sources
From Longevity Unmasked by Afshine Ash Emrani, MD, FACC. Medical disclaimer. This book is for education. It is not medical advice, and reading it does not make you my patient or create a doctor-patient relationship. Nothing here is meant to diagnose, treat, cure, or prevent any disease. Medicine is personal: a test, drug, supplement, or exercise plan that helps one person can harm another. Do not start, stop, or change any medication or treatment because of something you read in these pages. Talk with a licensed clinician who knows your history first. If you think you are having a medical emergency, call 911. The author disclaims responsibility for any loss or harm arising from use of the information in this book.